Champions Manchester City (1.57) travel to Sunderland (7.5) hoping to eradicate the 1-0 defeat they suffered in the corresponding fixture last season.
Roberto Mancini’s men are the only Premier League side yet to lose on the road, and will be confident playing a side whose home form only betters the bottom three teams in the division.
Fifth place Everton (1.53) host struggling Wigan Athletic (7.0) knowing that three points could take them to third place.
The Toffee’s are unbeaten in six games while the Latic’s, who are in the relegation zone on goal difference, have taken just one point from the last fifteen available.
Tottenham Hotspur (2.1) could also rise to third place if they win at Aston Villa (3.8) and other results go their way.
The visitors have lost three of their last four away games in the league, whilst Villa, will be hoping to get back on track after their humiliating defeat at Stamford Bridge on Sunday.
Elsewhere, West Brom (3.4), along with Everton and Spurs, currently have thirty points, and travel to second from bottom Queens Park Rangers (2.38).
Bottom of the table Reading (3.0), who were unlucky to lose to the Champions last time out, host a Swansea City (2.5) side fresh from holding league leaders Manchester United on Sunday.
Finally, Fulham (1.97) will be hoping to improve on a run that has seen them win just once in ten games as they host Southampton (4.5), who sit just above the relegation zone on goal difference.